Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.
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Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structureStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsProtein-like Tertiary Folding Behavior from Heterogeneous BackbonesFolding thermodynamics of protein-like oligomers with heterogeneous backbonesHuman iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arraysFolding and function in α/β-peptides: targets and therapeutic applications.Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes.Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold.Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.An overview of peptide and peptoid foldamers in medicinal chemistry.Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows.Targeting recognition surfaces on natural proteins with peptidic foldamersIterative Nonproteinogenic Residue Incorporation Yields α/β-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF.Protein Camouflage: Supramolecular Anion Recognition by Ubiquitin.α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.An α-Helix-Mimicking 12,13-Helix: Designed α/β/γ-Foldamers as Selective Inhibitors of Protein-Protein Interactions.A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides.Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle.α-Helix mimicry with α/β-peptides.Efficient access to enantiopure γ4-amino acids with proteinogenic side-chains and structural investigation of γ4-Asn and γ4-Ser in hybrid peptide helices.Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue Distribution.Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers.Modulating the Structural Properties of α,γ-Hybrid Peptides by α-Amino Acid Residues: Uniform 12-Helix Versus "Mixed" 12/10-Helix.Controlling the Helix Handedness of ααβ-Peptide Foldamers through Sequence Shifting.Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration.An α-Helix-Mimicking 12,13-Helix: Designed α/β/γ-Foldamers as Selective Inhibitors of Protein-Protein InteractionsAn iterative in silico and modular synthetic approach to aqueous soluble tercyclic α-helix mimetics
P2860
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P2860
Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Extending foldamer design beyo ...... elial growth factor signaling.
@en
type
label
Extending foldamer design beyo ...... elial growth factor signaling.
@en
prefLabel
Extending foldamer design beyo ...... elial growth factor signaling.
@en
P2093
P2860
P356
P1476
Extending foldamer design beyo ...... helial growth factor signaling
@en
P2093
Holly S Haase
Kimberly J Peterson-Kaufman
Samuel H Gellman
Sheeny K Lan Levengood
William L Murphy
P2860
P304
P356
10.1021/JA302469A
P407
P577
2012-05-01T00:00:00Z