Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells

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Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism.

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Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells

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Inhibition of DYRK1A disrupts ...... n human pluripotent stem cells

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Inhibition of DYRK1A disrupts ...... n human pluripotent stem cells

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Inhibition of DYRK1A disrupts ...... n human pluripotent stem cells

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Inhibition of DYRK1A disrupts ...... n human pluripotent stem cells

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Claire E Cuddy

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Edouard G Stanley

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Spencer J Williams

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Stephanie F Bellmaine

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

Pax6 is a human neuroectoderm cell fate determinant

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.

Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

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scholarly article

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10.7554/ELIFE.24502

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English

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2017-09-08T00:00:00Z

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28884684

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5656431

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Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells

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P2860

P2860

Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells

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P1476

P2093

P2860

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P356

P407

P478

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P698

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P356

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P2093

P2860

P31

P356

P407

P478

P50

P577

P698

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