Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer
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Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia BTargeted approaches to induce immune tolerance for Pompe disease therapyDevelopments in the treatment of hemophilia B: focus on emerging gene therapyAnimal models of hemophiliaRegulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features.Gene therapy for hemophiliaProgress and prospects: immune responses to viral vectorsCD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogsTolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityImmunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.AAV's anatomy: roadmap for optimizing vectors for translational successStrategies to modulate immune responses: a new frontier for gene therapyRegulatory T cells and immune tolerance to coagulation factor IX in the context of intramuscular AAV1 gene transfer.Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice.Hepatic gene transfer as a means of tolerance induction to transgene productsBALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.The potential of adeno-associated viral vectors for gene delivery to muscle tissue.AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsCell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.Immunomodulatory gene therapy in lysosomal storage disordersSafety of AAV factor IX peripheral transvenular gene delivery to muscle in hemophilia B dogs.Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cellsInduction of immune tolerance to a therapeutic protein by intrathymic gene delivery.Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy.RETRACTED: Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapyEfficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors.How tolerogenic dendritic cells induce regulatory T cellsDevelopment of Gene Transfer for Induction of Antigen-specific Tolerance.Portal vein delivery of viral vectors for gene therapy for hemophilia.Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockademiRNA-mediated silencing in hepatocytes can increase adaptive immune responses to adenovirus vector-delivered transgenic antigensAssessment of toxicity and biodistribution of recombinant AAV8 vector-mediated immunomodulatory gene therapy in mice with Pompe disease.Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cellsIntramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.Systemic administration of AAV8-α-galactosidase A induces humoral tolerance in nonhuman primates despite low hepatic expressionImpact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectorsGene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation.Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease
P2860
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P2860
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Induction and role of regulato ...... hepatic in vivo gene transfer
@en
type
label
Induction and role of regulato ...... hepatic in vivo gene transfer
@en
prefLabel
Induction and role of regulato ...... hepatic in vivo gene transfer
@en
P2093
P2860
P1433
P1476
Induction and role of regulato ...... hepatic in vivo gene transfer
@en
P2093
Bethany Mingle
Cox Terhorst
Eric Dobrzynski
Lixin Wang
Roland W Herzog
Sushrusha Nayak
P2860
P304
P356
10.1182/BLOOD-2007-02-073304
P407
P577
2007-04-16T00:00:00Z