Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. - Wikidata - awgldk - TriplyDB

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

http://www.wikidata.org/entity/Q41925220

about

Epigenetic regulation of hematopoietic stem cell aging Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1 Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management.Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?Translating leukemia stem cells into the clinical setting: Harmonizing the heterogeneity.Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses Cancer stem cell-directed therapies: recent data from the laboratory and clinic.Re-evaluation of various molecular targets located on CD34+CD38-Lin- leukemia stem cells and other cell subsets in pediatric acute myeloid leukemia.A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data.Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse Heterogeneity of clonal expansion and maturation-linked mutation acquisition in hematopoietic progenitors in human acute myeloid leukemia.Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid.Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells.Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML.The microenvironment-specific transformation of adult stem cells models malignant triton tumors.Stem cells and female reproduction.Right on target: eradicating leukemic stem cells.Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia.Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia.Further phenotypic characterization of the primitive lineage- CD34+CD38-CD90+CD45RA- hematopoietic stem cell/progenitor cell sub-population isolated from cord blood, mobilized peripheral blood and patients with chronic myelogenous leukemia.In Vitro and In Vivo Antitumor Effect of Anti-CD33 Chimeric Receptor-Expressing EBV-CTL against CD33 Acute Myeloid Leukemia CD34(+)/CD38(-) stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin Prognostic Relevance of Cytokine Receptor Expression in Acute Myeloid Leukemia: Interleukin-2 Receptor α-Chain (CD25) Expression Predicts a Poor Prognosis.Soluble Expression and Characterization of a New scFv Directed to Human CD123.Acute myeloid leukemia stem cells and CD33-targeted immunotherapy The evolving concept of cancer and metastasis stem cells T cells expressing CD123 chimeric antigen receptors for treatment of acute myeloid leukemia.Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia.Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells.Can immunotherapy specifically target acute myeloid leukemic stem cells?Targeting cancer stem cells.Therapeutic implications of leukemic stem cell pathways Immunoprofiling of leukemic stem cells CD34+/CD38-/CD123+ delineate FLT3/ITD-positive clones.T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia.Normal hematopoietic stem cells within the AML bone marrow have a distinct and higher ALDH activity level than co-existing leukemic stem cells.

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P2860

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

http://www.wikidata.org/entity/Q41925220

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Hematopoietic stem cells expre ...... apy of acute myeloid leukemia.

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Ama Z Rohatiner

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Catherine Simpson

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Daniel J Pearce

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David C Taussig

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Dominique Bonnet

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Gwenn-Aël H Danet-Desnoyers

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Jennifer L Luongo

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T Andrew Lister

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P2860

Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy

Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells

Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties.

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