Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment.
about
Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin BHepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying alleleThe role of the LDL receptor in apolipoprotein B secretion.Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins.Identification of two regions in apolipoprotein B100 that are exposed on the cytosolic side of the endoplasmic reticulum membranePalmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.Charged amino acid residues 997-1000 of human apolipoprotein B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cellsAmino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.Apolipoprotein B is synthesized in selected human non-hepatic cell lines but not processed into mature lipoprotein.Apolipoprotein B, a paradigm for proteins regulated by intracellular degradation, does not undergo intracellular degradation in CaCo2 cells.Studies on degradative mechanisms mediating post-translational fragmentation of apolipoprotein B and the generation of the 70-kDa fragment.Intracellular translocation and stability of apolipoprotein B are inversely proportional to the length of the nascent polypeptide.Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols.The enzymatic and non-enzymatic roles of protein-disulfide isomerase in apolipoprotein B secretion.Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells.Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport.Intracellular assembly and degradation of apolipoprotein B-100-containing lipoproteins in digitonin-permeabilized HEP G2 cells.Degradation of distinct assembly forms of immunoglobulin M occurs in multiple sites in permeabilized B cells.Chinese hamster ovary cells require the coexpression of microsomal triglyceride transfer protein and cholesterol 7alpha-hydroxylase for the assembly and secretion of apolipoprotein B-containing lipoproteins.Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum.The intracellular triacylglycerol/fatty acid cycle: a comparison of its activity in hepatocytes which secrete exclusively apolipoprotein (apo) B100 very-low-density lipoprotein (VLDL) and in those which secrete predominantly apoB48 VLDL.Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production.The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes.Minireview
P2860
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P2860
Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Degradation of apolipoprotein ...... plasmic reticulum compartment.
@en
type
label
Degradation of apolipoprotein ...... plasmic reticulum compartment.
@en
prefLabel
Degradation of apolipoprotein ...... plasmic reticulum compartment.
@en
P2093
P2860
P356
P1476
Degradation of apolipoprotein ...... plasmic reticulum compartment.
@en
P2093
P2860
P304
24924-24931
P356
10.1074/JBC.270.42.24924
P407
P577
1995-10-01T00:00:00Z