Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
about
The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerAdaptor protein Lnk inhibits c-Fms-mediated macrophage functionPathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Lnk constrains myeloproliferative diseases in mice.Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations.LNK (SH2B3): paradoxical effects in ovarian cancer.14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cellsAdaptor protein Lnk binds to and inhibits normal and leukemic FLT3.SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FJAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Role of the adaptor protein LNK in normal and malignant hematopoiesis.Molecular biology of Philadelphia-negative myeloproliferative neoplasmsGenetic and epigenetic alterations of myeloproliferative disorders.Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.LNK mutations and myeloproliferative disorders.The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.When the Brakes are Lost: LNK Dysfunction in Mice, Men, and Myeloproliferative Neoplasms.MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5.Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection.LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations.Selective Interference Targeting of Lnk in Umbilical Cord-Derived Late Endothelial Progenitor Cells Improves Vascular Repair, Following Hind Limb Ischemic Injury, via Regulation of JAK2/STAT3 Signaling.Lnk prevents inflammatory CD8⁺ T-cell proliferation and contributes to intestinal homeostasis.
P2860
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P2860
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Adaptor protein Lnk negatively ...... h myeloproliferative disorders
@en
type
label
Adaptor protein Lnk negatively ...... h myeloproliferative disorders
@en
prefLabel
Adaptor protein Lnk negatively ...... h myeloproliferative disorders
@en
P2093
P2860
P1433
P1476
Adaptor protein Lnk negatively ...... h myeloproliferative disorders
@en
P2093
H Phillip Koeffler
Katya Chumakova
Norihiko Kawamata
Saskia Gueller
Sigal Gery
P2860
P304
P356
10.1182/BLOOD-2007-05-089326
P407
P577
2007-08-10T00:00:00Z