Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.
about
Manufacturing of recombinant adeno-associated viral vectors for clinical trialsSynthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseasesPreclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathwaysAdeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo.DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition.siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.Molecular dissection of human Argonaute proteins by DNA shuffling.RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration.Development of gene therapy for treatment of age-related macular degeneration.Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa.Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioningAberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism.The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy.Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates.Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome.miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F InductionRecent advances in RNA interference therapeutics for CNS diseases.Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference.Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.Recombinant AAV as a platform for translating the therapeutic potential of RNA interference.Prospect of induced pluripotent stem cell genetic repair to cure genetic diseases.α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Gene therapy in animal models of autosomal dominant retinitis pigmentosaLentiviral vector-mediated RNA silencing in the central nervous system.Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones.RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies.Dissecting microRNA dysregulation in age-related macular degeneration: new targets for eye gene therapy.The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression.Caspase-3 and GFAP as early markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity.Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factorsSustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.shRNA-induced saturation of the microRNA pathway in the rat brain.Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin.GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity.Gene suppression approaches to neurodegeneration.
P2860
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P2860
Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Lethal toxicity caused by expr ...... ations for therapeutic design.
@en
type
label
Lethal toxicity caused by expr ...... ations for therapeutic design.
@en
prefLabel
Lethal toxicity caused by expr ...... ations for therapeutic design.
@en
P2093
P2860
P356
P1433
P1476
Lethal toxicity caused by expr ...... cations for therapeutic design
@en
P2093
J N Martin
M E Ehrlich
P Gonzalez-Alegre
P2860
P2888
P304
P356
10.1038/GT.2011.10
P577
2011-03-03T00:00:00Z
P5875
P6179
1009144261