Conformational flexibility and strand arrangements of the membrane-associated HIV fusion peptide trimer probed by solid-state NMR spectroscopy
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Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeOrigins of resistance to the HIVgp41 viral entry inhibitor T20.HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics.Multiple locations of peptides in the hydrocarbon core of gel-phase membranes revealed by peptide (13)C to lipid (2)H rotational-echo double-resonance solid-state nuclear magnetic resonance.REDOR solid-state NMR as a probe of the membrane locations of membrane-associated peptides and proteins.The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine designEffect of the HIV-1 fusion peptide on the mechanical properties and leaflet coupling of lipid bilayers.Solid-state NMR spectroscopy of protein complexes.A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide.Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy.Comparative analysis of membrane-associated fusion peptide secondary structure and lipid mixing function of HIV gp41 constructs that model the early pre-hairpin intermediate and final hairpin conformations.Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation.Major antiparallel and minor parallel β sheet populations detected in the membrane-associated human immunodeficiency virus fusion peptide.Solid-state NMR spectroscopy of human immunodeficiency virus fusion peptides associated with host-cell-like membranes: 2D correlation spectra and distance measurements support a fully extended conformation and models for specific antiparallel strandSolid-state nuclear magnetic resonance measurements of HIV fusion peptide 13CO to lipid 31P proximities support similar partially inserted membrane locations of the α helical and β sheet peptide structures.Detection of closed influenza virus hemagglutinin fusion peptide structures in membranes by backbone (13)CO- (15)N rotational-echo double-resonance solid-state NMR.Solid-state NMR spectroscopy of the HIV gp41 membrane fusion protein supports intermolecular antiparallel β sheet fusion peptide structure in the final six-helix bundle stateSolid-state nuclear magnetic resonance measurements of HIV fusion peptide to lipid distances reveal the intimate contact of beta strand peptide with membranes and the proximity of the Ala-14-Gly-16 region with lipid headgroups.HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of beta strand conformation with membrane cholesterol, and proximity to lipid headgroupspH-dependent vesicle fusion induced by the ectodomain of the human immunodeficiency virus membrane fusion protein gp41: Two kinetically distinct processes and fully-membrane-associated gp41 with predominant β sheet fusion peptide conformation.Residue-specific membrane location of peptides and proteins using specifically and extensively deuterated lipids and ¹³C-²H rotational-echo double-resonance solid-state NMR.Irregular structure of the HIV fusion peptide in membranes demonstrated by solid-state NMR and MD simulations.13C-13C and (15)N-(13)C correlation spectroscopy of membrane-associated and uniformly labeled human immunodeficiency virus and influenza fusion peptides: amino acid-type assignments and evidence for multiple conformations.Molecular dynamics simulations and conductance studies of the interaction of VP1 N-terminus from Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes.Solid-state nuclear magnetic resonance (NMR) spectroscopy of human immunodeficiency virus gp41 protein that includes the fusion peptide: NMR detection of recombinant Fgp41 in inclusion bodies in whole bacterial cells and structural characterization o
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P2860
Conformational flexibility and strand arrangements of the membrane-associated HIV fusion peptide trimer probed by solid-state NMR spectroscopy
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Conformational flexibility and ...... y solid-state NMR spectroscopy
@en
type
label
Conformational flexibility and ...... y solid-state NMR spectroscopy
@en
prefLabel
Conformational flexibility and ...... y solid-state NMR spectroscopy
@en
P2093
P2860
P356
P1433
P1476
Conformational flexibility and ...... y solid-state NMR spectroscopy
@en
P2093
David P Weliky
Michele L Bodner
Zhaoxiong Zheng
P2860
P304
12960-12975
P356
10.1021/BI0615902
P407
P577
2006-10-01T00:00:00Z