Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. - Wikidata - awgldk - TriplyDB

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

http://www.wikidata.org/entity/Q41993255

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Age-related neuroinflammatory changes negatively impact on neuronal function From inflammation to sickness and depression: when the immune system subjugates the brain Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders Neuroinflammation in the normal aging hippocampus Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior Learning and memory ... and the immune system.Regulation of learning and memory by meningeal immunity: a key role for IL-4 Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis.Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.Old Maids: Aging and Its Impact on Microglia Function.Differential sensitivity to endotoxin exposure in young and middle-age mice Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease.TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide.Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior.Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge Inflammation-associated depression: from serotonin to kynurenine Neurobiological studies of fatigue.At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response.Inflammasomes in neuroinflammation and changes in brain function: a focused review.Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia Memory impairments in healthy aging: Role of aging-induced microglial sensitization.Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies.Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide.Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress.Cancer induces inflammation and depressive-like behavior in the mouse: modulation by social housing.

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P2860

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

http://www.wikidata.org/entity/Q41993255

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Aging exacerbates depressive-l ...... ripheral innate immune system.

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Aging exacerbates depressive-l ...... eripheral innate immune system

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Jason O'Connor

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Jing Chen

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Jonathan P Godbout

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Maïté Moreau

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Nathan L Sparkman

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P2860

Cytokines sing the blues: inflammation and the pathogenesis of depression

Chronic stress and age-related increases in the proinflammatory cytokine IL-6

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Immune activation and degradation of tryptophan in coronary heart disease

Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Gene expression profile of aging and its retardation by caloric restriction

Serotonergic gene expression and depression: implications for developing novel antidepressants.

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5774003

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