Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases.
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Evolution of Efficient Modular Polyketide Synthases by Homologous RecombinationInversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.Frontiers and opportunities in chemoenzymatic synthesis.Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Substrate controlled divergence in polyketide synthase catalysis.Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.A conformational NMR analysis of methymycin aglycones: complete and unambiguous assignments of stereochemically diverse glycosylated methymycin analogs by 1D and 2D NMR techniques and molecular modeling.Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.
P2860
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P2860
Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@en
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@nl
type
label
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@en
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@nl
prefLabel
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@en
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@nl
P2093
P2860
P356
P1476
Synthesis and biochemical anal ...... kromycin polyketide synthases.
@en
P2093
David H Sherman
Jeffrey D Kittendorf
Jonathan D Mortison
P2860
P304
15784-15793
P356
10.1021/JA9060596
P407
P577
2009-11-01T00:00:00Z