Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

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A guilt-by-association mutation network in LGL leukemia.STAT5BN642H is a driver mutation for T cell neoplasia.Large granular lymphocyte cells and immune dysregulation diseases - the chicken or the egg?

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Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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Genomic landscape characteriza ...... th a systems genetics approach

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A Binatti

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A Coppe

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J Maciejewski

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M Clemente

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M Herling

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S Bortoluzzi

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Somatic STAT3 mutations in large granular lymphocytic leukemia

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.

A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells.

Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

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leu.2017.49

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1243-1246

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scholarly article

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10.1038/LEU.2017.49

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Satu Mustjoki

Emma I Andersson

Vanessa Rebecca Gasparini

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2017-02-07T00:00:00Z

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1083687796

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28167832

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Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

about

P2860

P2860

Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

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P1433

P1476

P2093

P2860

P2888

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P6179

P698

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