Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β
about
Severe renal mass reduction impairs recovery and promotes fibrosis after AKIChemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitroLPA receptor signaling: pharmacology, physiology, and pathophysiology.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.Autophagy regulates TGF-β expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction.Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.Tubular cell phenotype in HIV-associated nephropathy: role of phospholipid lysophosphatidic acid.Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstructionNew renal drug development to face chronic renal disease.Promising pharmacological directions in the world of lysophosphatidic Acid signaling.Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression.Progression of chronic kidney disease: too much cellular talk causes damage.Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI.TGF-β and renal fibrosis: a Pandora's box of surprises.Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.CTGF Is Expressed During Cystic Remodeling in the PKD/Mhm (cy/+) Rat Model for Autosomal-Dominant Polycystic Kidney Disease (ADPKD).Role of lysophosphatidic acid and its receptors in the kidney.Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.Fibrosis without fibroblast TGF-β receptors?Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.Transforming growth factor-β1 and lysophosphatidic acid activate integrin β6 gene promoter in Hep-3B cells.Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder
P2860
Q28388800-6307C077-E6AB-42E8-BC2A-D5884FF20292Q28828149-3E5FADB1-FB65-4FAA-8E48-004DFE0EECCFQ33825153-B54804DA-B02F-4A95-B99C-74A225FAACBCQ33840143-D6D96EE7-9FAE-4AA7-9CD1-EC32BC86511DQ33887329-886AA778-952E-4E85-AB7E-6F6CCBD00BDFQ34568775-EC99132C-3D54-47AA-BB4C-07F6C3EF4062Q35002110-343612BC-7DDE-4255-9962-A785B871343BQ35008515-FB38EEFE-6611-4D99-94F3-EDA7DF8EE5B9Q35120757-D60F4865-65AB-432E-B71D-5E1A1C42094CQ35924492-05364227-F406-4233-9171-518A2CD65162Q37041558-D6A32C21-0D50-4A2F-BDB0-2282DEB938CBQ38246640-E7D913C8-B231-4619-865F-5B7CF8702660Q38320338-197A0D36-4A22-4791-B04A-FF979F39A9B1Q38391570-110951C9-F8EA-47CA-BD2B-AA984B120F67Q38988806-4DB47F75-2E4D-4840-B8D0-8C5FFE1568E5Q39277013-88CAF12E-DC08-43CB-B068-D4378F277D2BQ39901297-52C5E1E2-89BD-4E2D-BD3D-A3995D47771FQ42531545-015B4F41-3F77-40A6-9ECC-374FC595704CQ45998425-563883DE-73F6-4E48-8A53-36FD8CE7F715Q47616685-993F6029-669E-4801-9E84-BE708ED815E3Q47758727-E337FCDA-FC75-435B-AD93-0198265FE372Q47817491-A16248E6-A1EC-43A5-9241-BE8B8310847EQ49886697-55E37C5E-607F-4B99-8B9B-44BA3C02939DQ51346034-A54DD457-3BF9-4D17-9BE2-C7F9D3C7123EQ55248001-AC3DA950-55B6-4C3D-B51F-0D4A01C6830CQ57050372-50215E69-7A34-4172-936D-C30D49066BDB
P2860
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@en
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@nl
type
label
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@en
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@nl
prefLabel
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@en
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@nl
P2093
P2860
P1476
Lysophosphatidic acid increase ...... -dependent activation of TGF-β
@en
P2093
Joel M Weinberg
Manjeri A Venkatachalam
Pothana Saikumar
Prajjal K Singha
Rongpei Lan
Shelia M Violette
P2860
P304
P356
10.1016/J.AJPATH.2012.06.035
P407
P577
2012-08-10T00:00:00Z