Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. - Wikidata - awgldk - TriplyDB

Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.

Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.

http://www.wikidata.org/entity/Q42046068

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A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis Cell cycle-regulated trafficking of human telomerase to telomeres The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans A new pathway in the control of the initiation of puberty: the MKRN3 gene Gene overexpression: uses, mechanisms, and interpretation MKRN1 Induces Degradation of West Nile Virus Capsid Protein by Functioning as an E3 Ligase Telomerase Regulation from Beginning to the End Role of E3 ubiquitin ligases in gastric cancer A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain InTERTesting association between telomerase, mTOR and phytochemicals Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation.Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene.The biogenesis and regulation of telomerase holoenzymes Regulation of the human catalytic subunit of telomerase (hTERT).Telomere maintenance mechanisms in cancer: clinical implications Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies.Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity.Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.Positive and negative regulation of Tetrahymena telomerase holoenzyme.Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability.Biogenesis of telomerase ribonucleoproteins Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF New molecular markers in resistant B-CLL.Chromatin structure in telomere dynamics Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal.Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.Physiological assembly and activity of human telomerase complexes Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancer UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo Telomeres and telomerase in cancer Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.

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Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.

http://www.wikidata.org/entity/Q42046068

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@en

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@nl

type

label

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@en

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@nl

prefLabel

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@en

Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

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Genes & Development

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Ubiquitin ligase MKRN1 modulat ...... hrough a proteolysis of hTERT.

@en

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In Kwon Chung

http://www.w3.org/2001/XMLSchema#string

Jun Hyun Kim

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Mark T Muller

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Mi Ran Kang

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Sue-Young Oh

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Sun-Mi Park

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Tae H Lee

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P2860

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

Involvement of 14-3-3 proteins in nuclear localization of telomerase

Mechanisms underlying ubiquitination

Functional requirement of p23 and Hsp90 in telomerase complexes

RING finger proteins: mediators of ubiquitin ligase activity

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase

Telomere length regulation

Myc activates telomerase

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776-781

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10.1101/GAD.1289405

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7

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19

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15805468

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telomere length

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1074314

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