about
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.What is the role of amyloid precursor protein dimerization?Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexEpigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer diseaseTemplated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer diseaseHeterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in CellsInhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract.Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta.Correlation between beta-amyloid peptide production and human APP-induced neuronal death.In vitro screening on β-amyloid peptide production of plants used in traditional medicine for cognitive disorders.Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis.Structural features of the KPI domain control APP dimerization, trafficking, and processing.Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties.Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.Pharmacological, molecular and functional characterization of vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptors in the rat pineal gland.Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway.Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.Contribution of Kunitz Protease Inhibitor and Transmembrane Domains to Amyloid Precursor Protein HomodimerizationSex-regulated gene dosage effect of PPARα on synaptic plasticityGlucocorticoids, but not dopamine, negatively regulate the melanotrophic activity of the rabbit pituitary intermediate lobeA mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo-neurohypophysial axisAmyloid Precursor Protein (APP) controls the expression of the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4) and synaptic GABA release
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Pascal Kienlen-Campard
@ast
Pascal Kienlen-Campard
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Pascal Kienlen-Campard
@es
Pascal Kienlen-Campard
@nl
Pascal Kienlen-Campard
@sl
type
label
Pascal Kienlen-Campard
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Pascal Kienlen-Campard
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Pascal Kienlen-Campard
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Pascal Kienlen-Campard
@nl
Pascal Kienlen-Campard
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Pascal Kienlen
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prefLabel
Pascal Kienlen-Campard
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Pascal Kienlen-Campard
@en
Pascal Kienlen-Campard
@es
Pascal Kienlen-Campard
@nl
Pascal Kienlen-Campard
@sl
P108
P106
P1153
6602922267
P21
P2798
P31
P496
0000-0003-1086-2942
P569
2000-01-01T00:00:00Z