Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. - Wikidata - awgldk - TriplyDB

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

http://www.wikidata.org/entity/Q42061898

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The regulation of neuronal mitochondrial metabolism by calcium The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications Structure and function of the mitochondrial calcium uniporter complex Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability.Imaging of mitochondrial Ca2+ dynamics in astrocytes using cell-specific mitochondria-targeted GCaMP5G/6s: mitochondrial Ca2+ uptake and cytosolic Ca2+ availability via the endoplasmic reticulum store.Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo.Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death.Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells.The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons Transient mitochondrial permeability transition mediates excitotoxicity in glutamate-sensitive NSC34D motor neuron-like cells Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish.The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders.The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation.Calcium-permeable ion channels in control of autophagy and cancer Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study.Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling.Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.The mitochondrial calcium uniporter in the heart: energetics and beyond.Mitochondrial dynamics in neuronal injury, development and plasticity.Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations.Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease.Mitochondria, Bioenergetics and Excitotoxicity: New Therapeutic Targets in Perinatal Brain Injury DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter.Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.Mitochondria Maintain Distinct Ca2+ Pools in Cone Photoreceptors.CMT-linked loss-of-function mutations in GDAP1 impair store-operated Ca2+ entry-stimulated respiration.

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Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

http://www.wikidata.org/entity/Q42061898

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年论文

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name

Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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Nature Communications

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Mitochondrial calcium uniporte ...... ctive nuclear calcium signals.

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P2093

Anna M Hagenston

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Hilmar Bading

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Jing Qiu

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Marc-Andre Martel

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Niclas Kneisel

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Paul A Skehel

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Yan-Wei Tan

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P2860

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells

Activity-dependent regulation of inhibitory synapse development by Npas4

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

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10.1038/NCOMMS3034

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4

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Giles E. Hardingham

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239942854

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23774321

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3709514

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