The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD.
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Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice.The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder.Differences in the performance of NK1R-/- ('knockout') and wildtype mice in the 5‑Choice Continuous Performance Test.The NK1R-/- mouse phenotype suggests that small body size, with a sex- and diet-dependent excess in body mass and fat, are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder.Perseveration by NK1R-/- ('knockout') mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice Continuous Performance Test.The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs.
P2860
The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD.
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The behavioural response of mi ...... profile in treatment of ADHD.
@en
The behavioural response of mi ...... profile in treatment of ADHD.
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type
label
The behavioural response of mi ...... profile in treatment of ADHD.
@en
The behavioural response of mi ...... profile in treatment of ADHD.
@nl
prefLabel
The behavioural response of mi ...... profile in treatment of ADHD.
@en
The behavioural response of mi ...... profile in treatment of ADHD.
@nl
P2093
P2860
P356
P1476
The behavioural response of mi ...... profile in treatment of ADHD.
@en
P2093
Ashley J Porter
David J Heal
Julia A Dudley
Katharine Pillidge
S Clare Stanford
Yuan-Chen Tsai
P2860
P304
P356
10.1111/BPH.12860
P407
P577
2014-10-01T00:00:00Z