Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering
about
In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions.Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity.Factors affecting the physical stability (aggregation) of peptide therapeutics.Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration.
P2860
Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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2016年學術文章
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2016年學術文章
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name
Mitigation of reversible self- ...... tructure-guided Fv engineering
@en
Mitigation of reversible self- ...... tructure-guided Fv engineering
@nl
type
label
Mitigation of reversible self- ...... tructure-guided Fv engineering
@en
Mitigation of reversible self- ...... tructure-guided Fv engineering
@nl
prefLabel
Mitigation of reversible self- ...... tructure-guided Fv engineering
@en
Mitigation of reversible self- ...... tructure-guided Fv engineering
@nl
P2093
P2860
P1476
Mitigation of reversible self- ...... tructure-guided Fv engineering
@en
P2093
Hasige A Sathish
James C Geoghegan
Melissa Damschroder
Reza Esfandiary
Ryan Fleming
Steven M Bishop
P2860
P304
P356
10.1080/19420862.2016.1171444
P577
2016-04-06T00:00:00Z