Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.

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Predictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis.

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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.

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2014 nî lūn-bûn

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Synthesis and Biological Evalu ...... nd Selective Pim-1 Inhibitors.

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Adrianne Clifford

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Ashley Chan

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Benjamin G Brenning

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Jason M Foulks

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Koc-Kan Ho

http://www.w3.org/2001/XMLSchema#string

Michael V McCullar

http://www.w3.org/2001/XMLSchema#string

Shannon Merx

http://www.w3.org/2001/XMLSchema#string

Shuping Lai

http://www.w3.org/2001/XMLSchema#string

Steven B Kanner

http://www.w3.org/2001/XMLSchema#string

Steven G Kultgen

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P2860

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach

A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas

Comprehensive analysis of kinase inhibitor selectivity

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

Pyrazolo[1,5-a]pyrimidines. Identification of the privileged structure and combinatorial synthesis of 3-(hetero)arylpyrazolo[1,5-a]pyrimidine-6-carboxamides.

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.

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10.1021/ML500300C

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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.

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P2860

P2860

Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.

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