Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
about
The structural biology of Toll-like receptorsMyD88: a central player in innate immune signalingTLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphologyCell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes InfectionRNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization.Rare variants in MYD88, IRAK4 and IKBKG and susceptibility to invasive pneumococcal disease: a population-based case-control studyRare and common variants: twenty arguments.Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.Application potential of toll-like receptors in cancer immunotherapy: Systematic review.The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.Similar Structures but Different Roles - An Updated Perspective on TLR Structures.A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.HMGB1: The Central Cytokine for All Lymphoid Cells.Case-control study and mRNA expression analysis reveal the MyD88 gene is associated with digestive disorders in rabbit.Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER).Biochemical Isolation of the Myddosome from Murine Macrophages.Defective MyD88 does not oligomerize within the activated TLR2/4 complexDefective MyD88 does not oligomerize within the complex of activated TLR5MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88Defective MyD88 and IRAK4 but not TLR-2 expression in HIV+ individuals with latent tuberculosis infection.
P2860
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P2860
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@en
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@nl
type
label
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@en
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@nl
prefLabel
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@en
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@nl
P2093
P2860
P356
P1476
Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.
@en
P2093
Alexander N R Weber
Andriy V Kubarenko
Anna Rautanen
Julie George
Nicholas J Gay
Tara C Mills
P2860
P304
P356
10.1074/JBC.M110.159996
P407
P577
2010-10-21T00:00:00Z