Inhibition of Rho kinases enhances the degradation of mutant huntingtin. - Wikidata - awgldk - TriplyDB

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

http://www.wikidata.org/entity/Q42110822

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The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment.Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst.Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics Autophagy and SQSTM1 on the RHOA(d) again: emerging roles of autophagy in the degradation of signaling proteins.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis.Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.Toward understanding Machado-Joseph disease ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease.Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.Role of androgen receptor polyQ chain elongation in Kennedy's disease and use of natural osmolytes as potential therapeutic targets.Potential therapeutic targets in polyglutamine-mediated diseases.Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson's Disease.Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25 Nanoparticulate strategies for the treatment of polyglutamine diseases by halting the protein aggregation process.Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells.Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin.Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Approaches for discovering novel bioactive small molecules targeting autophagy.Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.Therapeutic effect of Rho kinase inhibitor FSD-C10 in a mouse model of Alzheimer's disease

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P2860

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

http://www.wikidata.org/entity/Q42110822

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

2009年论文

@zh

2009年论文

@zh-cn

name

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@en

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@nl

type

label

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@en

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@nl

prefLabel

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@en

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

@nl

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Journal of Biological Chemistry

P1476

Inhibition of Rho kinases enhances the degradation of mutant huntingtin

@en

P2093

Anand Goswami

http://www.w3.org/2001/XMLSchema#string

Haruko Miyazaki

http://www.w3.org/2001/XMLSchema#string

Misako Okuno

http://www.w3.org/2001/XMLSchema#string

Nobuyuki Nukina

http://www.w3.org/2001/XMLSchema#string

Yoshihiro Kino

http://www.w3.org/2001/XMLSchema#string

P2860

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

Huntington's disease genetics

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

Rocks: multifunctional kinases in cell behaviour

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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13153-13164

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10.1074/JBC.M809229200

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19

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284

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2676047

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