about
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsAntihypertensive drug guanabenz is active in vivo against both yeast and mammalian prionsProtein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugsThe toll-like receptor agonist imiquimod is active against prionsRoscovitine targets, protein kinases and pyridoxal kinaseAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Investigation of N-hydroxythalidomide in vitro stability and comparison to other N-substituted derivatives.FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects.Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding.The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections.Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophySpecific Triazine Herbicides Induce Amyloid-β42 Production.Use of ATP analogs to inhibit HIV-1 transcription.Small-molecule inducers of Aβ-42 peptide production share a common mechanism of actionModulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Design of cocaethylene and cocaine conjugates to produce highly selective polyclonal antibodies.Antiprion drugs as chemical tools to uncover mechanisms of prion propagation.Cyclin-dependent kinase inhibitors: a survey of recent patent literature.Cyclin-dependent kinase inhibitors closer to market launch?Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.Procedure for identification and characterization of drugs efficient against mammalian prion: from a yeast-based antiprion drug screening assay to in vivo mouse models.Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.A yeast-based assay to isolate drugs active against mammalian prions.The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition.Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell linesCDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.
P50
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P50
description
onderzoeker
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name
Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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type
label
Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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prefLabel
Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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Hervé Galons
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P214
P106
P21
P213
0000 0000 0106 2394
P214
P31
P569
2000-01-01T00:00:00Z
P735
P7859
viaf-54319137