Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique.
about
Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolismDynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptorApplications of stable isotopes in clinical pharmacologyThin-layer chromatography separation of enantiomers of verapamil using macrocyclic antibiotic as a chiral selector.The mechanism of action of the optical enantiomers of verapamil against ischaemia-induced arrhythmias in the conscious rat.Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil.Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate.Use of pseudoracemic nitrendipine to elucidate the metabolic steps responsible for stereoselective disposition of nitrendipine enantiomersStereoselective disposition of mexiletine in manPharmacokinetics and pharmacodynamics of R- and S-gallopamil during multiple dosingBioequivalence of racemic drugs.Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme inductionPharmacokinetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil.Phase I and pharmacokinetic study of D-verapamil and doxorubicin.Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamilStereoselective drug disposition: potential for misinterpretation of drug disposition data.Chiral aspects of drug action at ion channels: a commentary on the stereoselectivity of drug actions at voltage-gated ion channels with particular reference to verapamil actions at the Ca2+ channel.Stereoselectivity in clinical pharmacokinetics and drug development.Chirality: pharmacokinetics and pharmacodynamics in 3 dimensions.Stereoselectivity: an issue of significant importance in clinical pharmacology.On the other hand: the stereoselectivity of drug action at ion channels.Stereochemistry in pharmacotherapy: when mirror images are not identical.Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P-450 monooxygenases.The clinical implications of first-pass metabolism: treatment strategies for the 1990s.Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects.Pharmacokinetics of the enantiomers of verapamil in the dog.Enantioselective assays in comparative bioavailability studies of racemic drug formulations: nice to know or need to know?Pharmacokinetics of conventional and slow-release verapamil.Pharmacokinetics and pharmacodynamics of verapamil following sublingual and oral administration to healthy volunteers.Influence of metabolites on protein binding of verapamil enantiomers.Evaluation of potential pharmacodynamic and pharmacokinetic interactions between verapamil and propranolol in normal subjects.Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition.Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic.Pharmacokinetics of controlled-release verapamil in healthy volunteers and patients with hypertension or angina.Pharmacokinetics and dynamics of penbutolol in humans: evidence for pathway-specific stereoselective clearance.Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.The influence of cimetidine on the pharmacokinetics of the enantiomers of verapamil in the dog during multiple oral dosing.Simultaneous first-order and capacity-limited elimination kinetics after oral administration of verapamil.Effects of verapamil on etoposide pharmacokinetics after intravenous and oral administration in rats.Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat.
P2860
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P2860
Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
1984年论文
@zh
1984年论文
@zh-cn
name
Stereoselective first-pass met ...... th a stable isotope technique.
@en
Stereoselective first-pass met ...... th a stable isotope technique.
@nl
type
label
Stereoselective first-pass met ...... th a stable isotope technique.
@en
Stereoselective first-pass met ...... th a stable isotope technique.
@nl
prefLabel
Stereoselective first-pass met ...... th a stable isotope technique.
@en
Stereoselective first-pass met ...... th a stable isotope technique.
@nl
P2093
P2860
P1476
Stereoselective first-pass met ...... th a stable isotope technique.
@en
P2093
Eichelbaum M
Vogelgesang B
P2860
P304
P356
10.1111/J.1365-2125.1984.TB02536.X
P407
P577
1984-11-01T00:00:00Z