Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis

Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis

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http://www.wikidata.org/entity/Q42132854
Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamilyHuman aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.Promiscuity and diversity in 3-ketosteroid reductases.Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.Kinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily.Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily.
P2860

Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis

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http://www.wikidata.org/entity/Q42132854
description
1997 nî lūn-bûn
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1997年の論文
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1997年論文
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1997年論文
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1997年論文
@zh-hk
1997年論文
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1997年論文
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1997年论文
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1997年论文
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1997年论文
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name
Identification of amino acid r ...... s by site-directed mutagenesis
@en
Identification of amino acid r ...... s by site-directed mutagenesis
@nl
type
label
Identification of amino acid r ...... s by site-directed mutagenesis
@en
Identification of amino acid r ...... s by site-directed mutagenesis
@nl
prefLabel
Identification of amino acid r ...... s by site-directed mutagenesis
@en
Identification of amino acid r ...... s by site-directed mutagenesis
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P478
P577
P5875
P698
P932
P356
P1433
P1476
Identification of amino acid r ...... s by site-directed mutagenesis
@en
P2093
P2860
P304
P31
P356
P407
P478
P577
P5875
P698
P932