A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.
about
Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreusInsights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae.Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogsDiversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.Engineering synthetic recursive pathways to generate non-natural small molecules.Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.Structural analysis of protein-protein interactions in type I polyketide synthasesPKS and NRPS release mechanisms.Convergent strategies in biosynthesis.Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin.Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.Navigating the fungal polyketide chemical space: from genes to molecules.Analysis of the Sequences, Structures, and Functions of Product-Releasing Enzyme Domains in Fungal Polyketide Synthases.Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase.A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.Macrodiolide formation by the thioesterase of a modular polyketide synthase.
P2860
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P2860
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.
description
2009 nî lūn-bûn
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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name
A thioesterase from an iterati ...... ng through product offloading.
@en
A thioesterase from an iterati ...... ng through product offloading.
@nl
type
label
A thioesterase from an iterati ...... ng through product offloading.
@en
A thioesterase from an iterati ...... ng through product offloading.
@nl
prefLabel
A thioesterase from an iterati ...... ng through product offloading.
@en
A thioesterase from an iterati ...... ng through product offloading.
@nl
P2093
P2860
P356
P1433
P1476
A thioesterase from an iterati ...... ng through product offloading.
@en
P2093
Christopher N Boddy
Monica Wirz
P2860
P304
P356
10.1021/BI9009049
P407
P577
2009-07-01T00:00:00Z