Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. - Wikidata - awgldk - TriplyDB

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

http://www.wikidata.org/entity/Q42147260

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Deciphering the role of hedgehog signaling in pancreatic cancer Hedgehog Signaling in Pancreatic Fibrosis and Cancer Genomic alterations in pancreatic cancer and their relevance to therapy GEMMs as preclinical models for testing pancreatic cancer therapies Molecular Targeted Intervention for Pancreatic Cancer Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench Genetically engineered mouse models of pancreatic adenocarcinoma Personalized medicine in sporadic pancreatic cancer without homologous recombination-deficiency: are we any closer?Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway Pancreatic cancers require autophagy for tumor growth Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.Fms related tyrosine kinase 1 (Flt1) functions as an oncogene and regulates glioblastoma cell metastasis by regulating sonic hedgehog signaling.KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma Stromal response to Hedgehog signaling restrains pancreatic cancer progression.Pancreatic cancer and its stroma: a conspiracy theory Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.Smarter drugs emerging in pancreatic cancer therapy.Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Molecular characteristics of pancreatic ductal adenocarcinoma Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas.Deploying mouse models of pancreatic cancer for chemoprevention studies Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma.Understanding and targeting cancer stem cells: therapeutic implications and challenges.Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer.Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer.Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells.In vitro models of pancreatic cancer for translational oncology research.Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.

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Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

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P2860

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors

Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Functional discovery via a compendium of expression profiles.

Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer

Identification of pancreatic cancer stem cells

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

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