A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity
about
6-desfluoroquinolones as HIV-1 Tat-mediated transcription inhibitors.The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.Design, synthesis, and evaluation of WC5 analogues as inhibitors of human cytomegalovirus Immediate-Early 2 protein, a promising target for anti-HCMV treatment.The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses.Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.
P2860
Q37855902-460A64F4-6922-478E-8E99-03BDF2535CC2Q38962962-43295883-FDB6-48EE-990E-67A542199AB4Q39140795-40A8431E-1596-4F3D-AEA4-C916082120BDQ40334600-EFE2D18E-B435-4A05-AEA7-1F80DAE41512Q41571076-7A0689D5-C887-43E5-BFA0-480034040AB0Q42616123-83A0A8EB-3ABC-4A5F-A9EB-DEB4A810D10FQ55038212-11117567-D4F0-447D-9189-5BDF877587CB
P2860
A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
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2008年论文
@zh-cn
name
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@en
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@nl
type
label
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@en
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@nl
prefLabel
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@en
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@nl
P2093
P2860
P50
P356
P1476
A 6-aminoquinolone compound, W ...... human cytomegalovirus activity
@en
P2093
Beatrice Mercorelli
Elisa Sinigalia
Giulia Muratore
Maria Angela Biasolo
P2860
P304
P356
10.1128/AAC.00988-08
P407
P577
2008-11-17T00:00:00Z