Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
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Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discoveryStructure of HsaD, a steroid-degrading hydrolase, fromMycobacterium tuberculosisProbing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active siteCharacterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatisPiperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside MacrophagesStructure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversityInsight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme AKinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosisA highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosisExpression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferaseArylamine N-acetyltransferase 2 expression in the developing heartTackling tuberculosis: Insights from an international TB Summit in LondonIdentification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tubercularsKinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa.Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay.Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabGHomologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Arylamine N-acetyltransferases: what we learn from genes and genomes.Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.Arylamine N-acetyltransferases.Arylamine N-acetyltransferases in mycobacteria.Update on the pharmacogenetics of NATs: structural considerations.Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity.Cholesterol metabolism: a potential therapeutic target in Mycobacteria.Identification of the anti-mycobacterial functional properties of piperidinol derivatives.HT-SPOTi: A Rapid Drug Susceptibility Test (DST) to Evaluate Antibiotic Resistance Profiles and Novel Chemicals for Anti-Infective Drug Discovery.The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach.Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.Mycobacterium tuberculosis... Can we beat it? Report from a Euroscicon conference 2013.Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis.TB Summit 2014: prevention, diagnosis, and treatment of tuberculosis-a meeting report of a Euroscicon conference.Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.Reversibly acetylated lysine residues play important roles in the enzymatic activity of Escherichia coli N-hydroxyarylamine O-acetyltransferase.Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): a biochemical and computational study.Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case.Exploration of Piperidinols as Potential Antitubercular Agents
P2860
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P2860
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@en
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@nl
type
label
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@en
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@nl
prefLabel
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@en
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@nl
P2093
P2860
P50
P356
P1476
Arylamine N-acetyltransferase ...... epresents a novel drug target.
@en
P2093
Anna M Upton
Carolyn Sholto-Douglas-Vernon
Kevin J C Gibson
Matthew C Anderton
Rosangela P DaSilva
Sanjib Bhakta
Stuart Knutton
Tanya Parish
P2860
P304
P356
10.1084/JEM.20031956
P407
P577
2004-04-26T00:00:00Z