The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
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Transferrin-mediated cellular iron deliveryHow the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pHEngineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular AccumulationNoncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry.Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometryIntracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer.Identification of a kinetically significant anion binding (KISAB) site in the N-lobe of human serum transferrin.Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometryA loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping.The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin.Cellular and mitochondrial iron homeostasis in vertebrates3D single molecule tracking with multifocal plane microscopy reveals rapid intercellular transferrin transport at epithelial cell barriers.Molecular control of vertebrate iron homeostasis by iron regulatory proteinsA structural comparison of human serum transferrin and human lactoferrin.Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released.Inequivalent contribution of the five tryptophan residues in the C-lobe of human serum transferrin to the fluorescence increase when iron is released.A general map of iron metabolism and tissue-specific subnetworks.Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.Inhibition of transferrin iron release increases in vitro drug carrier efficacyConserved interaction between transferrin and transferrin-binding proteins from porcine pathogens.Excited-state lifetime studies of the three tryptophan residues in the N-lobe of human serum transferrin.Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins.The Transferrin Receptors, TfR1 and TfR2, Bind Transferrin through Differing Mechanisms.
P2860
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P2860
The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
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2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
@zh-hant
name
The molecular mechanism for re ...... transport protein transferrin.
@en
The molecular mechanism for re ...... transport protein transferrin.
@nl
type
label
The molecular mechanism for re ...... transport protein transferrin.
@en
The molecular mechanism for re ...... transport protein transferrin.
@nl
prefLabel
The molecular mechanism for re ...... transport protein transferrin.
@en
The molecular mechanism for re ...... transport protein transferrin.
@nl
P2093
P1433
P1476
The molecular mechanism for re ...... transport protein transferrin.
@en
P2093
Anne B Mason
Anthony M Giannetti
Caroline A Enns
Pamela J Björkman
Peter J Halbrooks
Todd M Vogt
P304
P356
10.1016/J.STR.2005.07.016
P577
2005-11-01T00:00:00Z