Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
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Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malariaStructural and Functional Studies of Aspergillus clavatus N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase,Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate ComplexesInhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesMolecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparumAntimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate ReductoisomeraseThe effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cellsStructure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor.Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate ReductoisomeraseExpression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy.Biochemistry of the non-mevalonate isoprenoid pathway.Novel antimalarial drug targets: hope for new antimalarial drugs.Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin.Effects of fosmidomycin on plant photosynthesis as measured by gas exchange and chlorophyll fluorescence.Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures.The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.Mechanistic insights into 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a key enzyme of the MEP terpenoid biosynthetic pathway.Chitosan-heparin polyelectrolyte multilayers on cortical bone: periosteum-mimetic, cytophilic, antibacterial coatings.Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase.A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.A cytosolic Arabidopsis D-xylulose kinase catalyzes the phosphorylation of 1-deoxy-D-xylulose into a precursor of the plastidial isoprenoid pathway.
P2860
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P2860
Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
@zh-hant
name
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@en
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@nl
type
label
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@en
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@nl
prefLabel
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@en
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@nl
P2093
P2860
P356
P1433
P1476
Isoprenoid biosynthesis as a t ...... e phosphate reducto-isomerase.
@en
P2093
Andréa Hemmerlin
Audrey Willem
Catherine Grosdemange-Billiard
Denis Tritsch
Lionel Kuntz
Michel Rohmer
Thomas J Bach
P2860
P304
P356
10.1042/BJ20041378
P407
P577
2005-02-01T00:00:00Z