Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats
about
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cellsTherapeutic effect of a poly(ADP-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and Th1 response.PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia.PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells.Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in micePoly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitisOxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis?Role of Txk, a member of the Tec family of tyrosine kinases, in immune-inflammatory diseases.Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation.The importance of NAD in multiple sclerosisPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading.Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells.Review: NAD +: a modulator of immune functions.Metabolic checkpoints in activated T cells.Beyond DNA repair, the immunological role of PARP-1 and its siblings.A further TWEAK to multiple sclerosis pathophysiology.Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment.Caspase 3 activation and PARP cleavage in lymphocytes from newborn babies of diabetic mothers with unbalanced glycaemic control.
P2860
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P2860
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Inhibitors of poly(ADP-ribose) ...... mune encephalomyelitis in rats
@en
type
label
Inhibitors of poly(ADP-ribose) ...... mune encephalomyelitis in rats
@en
prefLabel
Inhibitors of poly(ADP-ribose) ...... mune encephalomyelitis in rats
@en
P2860
P356
P1476
Inhibitors of poly(ADP-ribose) ...... mune encephalomyelitis in rats
@en
P2093
Alberto Chiarugi
P2860
P304
P356
10.1038/SJ.BJP.0704934
P407
P577
2002-11-01T00:00:00Z