about
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptorPurinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and deathCNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptorThe recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repairFrontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor.Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiationThe regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs.Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation.Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury.A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitroRole of purinergic signalling in neuro-immune cells and adult neural progenitors.Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine.Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate.Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?Purinergic transmission in brain tumors and its impact on drug development.SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells.Different properties of P2X(7) receptor in hippocampal and cortical astrocytes.Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes.Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17.Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases.Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination.The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitizationVentral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: Effect of neuroprotective agentsAgonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene LigandsPurple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain: Role of MicrogliaRegulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin RepairRegulation and signaling of the GPR17 receptor in oligodendroglial cellsIn vivo silencing of miR-125a-3p promotes myelin repair in models of white matter demyelinationPathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell SignalingImprovement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drugLupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic BehaviorMicroRNAs change the games in central nervous system pharmacology
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
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ricercatore
@it
հետազոտող
@hy
name
Davide Lecca
@ast
Davide Lecca
@en
Davide Lecca
@es
Davide Lecca
@nl
Davide Lecca
@sl
type
label
Davide Lecca
@ast
Davide Lecca
@en
Davide Lecca
@es
Davide Lecca
@nl
Davide Lecca
@sl
prefLabel
Davide Lecca
@ast
Davide Lecca
@en
Davide Lecca
@es
Davide Lecca
@nl
Davide Lecca
@sl
P214
P1053
A-8850-2010
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P1153
23489536300
P21
P214
P31
P3829
P396
IT\ICCU\CFIV\273416
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0000-0002-3258-363X
P569
1977-01-01T00:00:00Z
P735
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viaf-307344468