Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.
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Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B)Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7AA single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasisBiochemical basis of regulation of human copper-transporting ATPasesCellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balanceMolecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypesCopper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxificationThe global responses of Mycobacterium tuberculosis to physiological levels of copperNH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cellsIn silico investigation of the ATP7B gene: insights from functional prediction of non-synonymous substitution to protein structure.The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding.Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake.Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites.Wilson's disease: a comprehensive review of the molecular mechanisms.Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7BMolecular events initiating exit of a copper-transporting ATPase ATP7B from the trans-Golgi networkATP7B expression in human breast epithelial cells is mediated by lactational hormones.The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin.Delivery of the Cu-transporting ATPase ATP7B to the plasma membrane in Xenopus oocytes.Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis.Mechanism of tumor resistance to cisplatin mediated by the copper transporter ATP7B.Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.The different intermolecular interactions of the soluble copper-binding domains of the menkes protein, ATP7A.Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial.ATP7B expression confers multidrug resistance through drug sequestrationDistinct functions of serial metal-binding domains in the Escherichia coli P1 B -ATPase CopA.An NMR study of the interaction of the N-terminal cytoplasmic tail of the Wilson disease protein with copper(I)-HAH1.Dynamic multibody protein interactions suggest versatile pathways for copper trafficking.The genetics of Wilson disease.In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding.Probing transient copper chaperone-Wilson disease protein interactions at the single-molecule level with nanovesicle trapping.The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system.The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics.Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast.The Structure of Metal Binding Domain 1 of the Copper Transporter ATP7B Reveals Mechanism of a Singular Wilson Disease Mutation.
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P2860
Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Intracellular trafficking of t ...... -terminal metal-binding sites.
@en
Intracellular trafficking of t ...... -terminal metal-binding sites.
@nl
type
label
Intracellular trafficking of t ...... -terminal metal-binding sites.
@en
Intracellular trafficking of t ...... -terminal metal-binding sites.
@nl
prefLabel
Intracellular trafficking of t ...... -terminal metal-binding sites.
@en
Intracellular trafficking of t ...... -terminal metal-binding sites.
@nl
P2093
P2860
P356
P1433
P1476
Intracellular trafficking of t ...... N-terminal metal-binding sites
@en
P2093
John Forbes
Julian F B Mercer
Michael A Cater
P2860
P304
P356
10.1042/BJ20031804
P407
P577
2004-06-01T00:00:00Z