Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. - Wikidata - awgldk - TriplyDB

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

http://www.wikidata.org/entity/Q42181013

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Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight Targeting ECM Disrupts Cancer Progression Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma.Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer Stromal biology and therapy in pancreatic cancer: a changing paradigm.UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.Hyaluronan in cancer - from the naked mole rat to nanoparticle therapy.A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells.Hyaluronic acid in digestive cancers.Hyaluronan stimulates pancreatic cancer cell motility.ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder.Is pulmonary hypertension a metabolic disease?Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities.Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going.ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis.Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma.The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer.The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma.Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells Shattering the castle walls: Anti-stromal therapy for pancreatic cancer Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

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P2860

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

http://www.wikidata.org/entity/Q42181013

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Accumulation of extracellular ...... eatic cancer microenvironment.

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Accumulation of extracellular ...... eatic cancer microenvironment.

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Accumulation of extracellular ...... reatic cancer microenvironment

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P2093

Chunmei Zhao

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Curtis B Thompson

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Gregory I Frost

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H Michael Shepard

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Jeffrey R Infante

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Michael A Jacobetz

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Netai C Singha

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Ping Jiang

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Rebecca Symons

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Ryan J Osgood

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P2860

Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity

The basics of epithelial-mesenchymal transition

Targeting HIF-1 for cancer therapy

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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2014

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Susan Zimmerman

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