Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. - Wikidata - awgldk - TriplyDB

Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

http://www.wikidata.org/entity/Q42183397

about

Managing osteoporosis in ulcerative colitis: something new?γδ T cell and other immune cells crosstalk in cellular immunity Harnessing the power of Vδ2 cells in cancer immunotherapy γδ T cells in cancer immunotherapy Endocytotic uptake of zoledronic acid by tubular cells may explain its renal effects in cancer patients receiving high doses of the compound Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic Ph+ leukemia model Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug.Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions.Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis.Targeting γδ T cells for immunotherapy of HIV disease Novel immunostimulatory effects of osteoclasts and macrophages on human γδ T cells.Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells.Do γδ T cells predict osteonecrosis of the jaw?Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid.Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats.Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo Challenges and future perspectives of T cell immunotherapy in cancer Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism.Influence of bisphosphonate treatment on medullary macrophages and osteoclasts: an experimental study.A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton.Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro.Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines.Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer.Anticancer properties of zoledronic acid.Pharmacokinetic evaluation of zoledronic acid.γδ T-APCs: a novel tool for immunotherapy?Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside.New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response.New role for an established drug? Bisphosphonates as potential anticancer agents.Potential therapeutic effects of oral bisphosphonates on the intestine.The multifunctionality of human Vγ9Vδ2 γδ T cells: clonal plasticity or distinct subsets?Human γδ T-cell responses in infection and immunotherapy: common mechanisms, common mediators?Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside.At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies.Current and future approaches to treat graft failure after allogeneic hematopoietic stem cell transplantation.Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy.Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment.

P2860

Q26864691-56620CBE-A188-4069-B27D-747C662F7082 Q27007775-39296EAF-0EBB-443B-A955-1221201346BC Q27027547-5F8A62D0-1D8B-491A-A690-099732459EF3 Q28068988-221AED25-5FFB-4C87-8DDB-DFD9B9FC43CC Q28543939-EF8B1BED-AAAE-4CEC-85B3-F58F396B87B2 Q33815423-5F6D4F53-3FE0-4384-AFE2-591A346DAB07 Q33920919-A16161D0-6684-44BD-B553-BB51884C691B Q33938500-6601155C-B99F-4143-B5DF-0371D4566FEE Q34018048-F6F233DF-EE50-49C2-B996-BBF799C50B53 Q34585223-F52C9B61-B623-44E0-8EE9-A63F1A3573BD Q34906361-0621795B-D88C-4459-9F64-0684C3224607 Q35008733-B196E004-2673-401D-93F4-6F315C98A901 Q35046087-C76C0BDC-ED87-43EB-8438-B1EE25DE0E4B Q35077632-BAD98494-EB91-4AC5-B4F3-0228064C0AE9 Q35093824-893E10B6-BBDA-416D-8957-709934926888 Q35155516-0C00BE03-2D9B-4A54-BD68-F3627C784BC1 Q35156294-BD4B5B78-AB62-445F-866C-EF6032ACA64A Q35843507-8BB435E4-C6A9-4058-9048-806C35E38E51 Q35889808-3BE50567-C415-4551-87E9-4B809F8A85D2 Q36253554-2DAF413A-1185-4B44-B58A-0CBBF16B9C32 Q36997869-BA85FEC2-1034-4E47-AB4B-446129571ACB Q37294760-786238C0-FD6B-4EDB-9532-2C52E1EF5270 Q37310557-80748523-231A-4221-A1C1-E1A511D6B38B Q37623726-FC3C3CA5-9744-4B36-9735-86E1C85F1C77 Q37655345-DCB955EB-1316-430F-8082-EE166580B5A4 Q37703392-9675F2FE-889B-478B-9589-A4286A907577 Q37794160-6600BD0F-9CDB-4FAF-8160-9959549F0CC1 Q37874629-F99CE5BB-F755-4F1D-AF74-670DE1B5DBCC Q37875768-9072624E-0704-4B7B-8CA3-50A898CCBF02 Q37876363-FD020E1D-033A-45EB-9E4D-E5731534898F Q37917774-8C1FBE33-AFE7-40D1-8D19-0C4598140AC3 Q37923744-2F3C0944-07FA-452B-A229-7C5C90680D7F Q37987554-FA9B8135-9774-45AD-8F9B-38235945B1A1 Q38016451-C905D783-E293-4446-A3C4-339511D4E010 Q38027044-52476B5A-07A9-4A82-90E1-F385FF17FE2E Q38051730-FCA5CF2C-5AD0-452E-9701-9D027B4C7B1F Q38149725-4CC48B26-E9B6-465E-BAAE-AED8DB609E92 Q38155240-7599E917-A9CC-4CF4-AB73-35978210B4A0 Q38265506-52E8624D-73CB-4F59-8B08-894819F7BB03 Q38287973-BD913DD4-5956-4A04-AB30-030986A60344

P2860

Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

http://www.wikidata.org/entity/Q42183397

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@en

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@nl

type

label

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@en

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@nl

prefLabel

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@en

Peripheral blood monocytes are ...... ugh accumulation of IPP/DMAPP.

@nl

P1433

Q42183397-2122CA5E-6E20-47C7-A734-2C463D965430

P1476

Q42183397-D69E3F1E-8931-48C9-8B6E-DDEE341FC527

P2093

Q42183397-2693835B-3D48-471F-B455-5C63DC11980B

Q42183397-DBA56F11-372A-418F-B3CD-811B26BCB7E5

Q42183397-EC3F1D9C-0852-4957-9334-F1790B86AF80

Q42183397-FEB577B7-E364-4FF6-B0D6-0B9BCCAEAD9D

P2860

Q42183397-1F15CAA0-78B1-4F26-8D11-618278EDE1D6

Q42183397-3B049D70-AD62-491A-BD1B-9C222EBC6899

Q42183397-44F46C1C-D689-4F45-8258-FEEB81B3CC26

Q42183397-57F68AF5-DA18-40EF-A0F4-2C30126BDC27

Q42183397-6AF71902-FA5A-4961-AC07-1943385859FF

Q42183397-98BE8593-DD42-4114-80C6-9B91293A8DA0

Q42183397-B50B03C0-F253-46F9-9C2C-CEBBDB48CE43

Q42183397-D7FEFDD5-3B5A-4ED3-964A-FA51A2A576DC

Q42183397-E2AF2D6D-B62C-4378-9D8E-7FC237B66B9A

Q42183397-ED3E0BA7-16BF-4D30-9D42-4AFCA6A68CB6

P304

Q42183397-9A9EBE69-8930-461F-A1F8-8FA02CD0DA9D

P31

Q42183397-854A17D2-A9FE-4754-975A-8F248417146D

P356

Q42183397-8666A39A-5BEE-40D5-BD66-0E74A13635B0

P407

Q42183397-834E4281-EE28-41CC-BA03-776DB359D605

P433

Q42183397-8C809BB2-36ED-4EC0-BAAC-13272F7FA80C

P478

Q42183397-173FDBF2-4104-41C6-84F5-71FCDA7F19C9

P50

Q42183397-217E1016-FE2A-4236-9EF3-E97DF6B2303E

Q42183397-C52DBCCA-E04F-4A88-9D23-50AAA9F54130

P577

Q42183397-48F66F7C-F27F-4F9A-AE0E-1C6B9A499D6C

P5875

Q42183397-0568EB7E-73E7-40F7-AC05-0089F64BBF9B

P698

Q42183397-27870526-E53D-42BD-B81C-0B5981E1692D

P932

Q42183397-03670C5B-CC55-4448-A818-EC6292651B74

P356

J.1365-2141.2008.07435.X

P1433

British Journal of Haematology

P1476

Peripheral blood monocytes are ...... ough accumulation of IPP/DMAPP

@en

P2093

Anke J Roelofs

http://www.w3.org/2001/XMLSchema#string

Hannu Mönkkönen

http://www.w3.org/2001/XMLSchema#string

Jukka Mönkkönen

http://www.w3.org/2001/XMLSchema#string

Marjo Jauhiainen

http://www.w3.org/2001/XMLSchema#string

P2860

The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins

Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells

Human Vgamma9Vdelta2 T cells: promising new leads for immunotherapy of infections and tumors.

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.

Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis.

Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human gamma delta T cells by aminobisphosphonate antigen.

Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

Development and validation of a highly sensitive RIA for zoledronic acid, a new potent heterocyclic bisphosphonate, in human serum, plasma and urine.

Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases.

Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

P304

245-250

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/J.1365-2141.2008.07435.X

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

144

http://www.w3.org/2001/XMLSchema#string

P50

Michael J. Rogers

P577

2008-11-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23480955

http://www.w3.org/2001/XMLSchema#string

P698

19016713

http://www.w3.org/2001/XMLSchema#string

P932

2659391

http://www.w3.org/2001/XMLSchema#string