Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
about
Alzheimer's disease--a panorama glimpseComplexation of two proteic insect inhibitors to the active site of chymotrypsin suggests decoupled roles for binding and selectivitySolution structure of a Kunitz-type chymotrypsin inhibitor isolated from the elapid snake Bungarus fasciatusIsolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle TickStructure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of InhibitionSystematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX InteractionsDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinStructure of the recombinant BPTI/Kunitz-type inhibitorrShPI-1A from the marine invertebrateStichodactyla helianthusStructural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2Design, docking, and evaluation of multiple libraries against multiple targets.Spatial chemical conservation of hot spot interactions in protein-protein complexes.The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture.Structural and energetic determinants of the S1-site specificity in serine proteases.The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Computational alanine scanning with linear scaling semiempirical quantum mechanical methods.Characterization of a novel serine protease inhibitor gene from a marine metagenome.Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitorMechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitorInsights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.Elapid snake venom analyses show the specificity of the peptide composition at the level of genera Naja and NotechisPolar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13LAtypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa.New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispaThe Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels.Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals.The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.Mechanisms of macromolecular protease inhibitorsAnalysis of serine proteinase-inhibitor interaction by alanine shaving.Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1).PCRPi: Presaging Critical Residues in Protein interfaces, a new computational tool to chart hot spots in protein interfaces.A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces.Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme.Selection of near-native poses in CAPRI rounds 13-19.Cleavage of peptide bonds bearing ionizable amino acids at P(1) by serine proteases with hydrophobic S(1) pocket.Secretion and assembly of calicivirus-like particles in high-cell-density yeast fermentations: strategies based on a recombinant non-specific BPTI-Kunitz-type protease inhibitor.Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes.Identification of hot spot residues at protein-protein interface.Recognition and stabilization of a unique CPRI--structural motif in cucurbitaceae family trypsin inhibitor peptides: molecular dynamics based homology modeling using the X-ray structure of MCTI-II.Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI.
P2860
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P2860
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Crystal structures of bovine c ...... rs with altered specificities.
@en
Crystal structures of bovine c ...... amyloid beta-protein precursor
@nl
type
label
Crystal structures of bovine c ...... rs with altered specificities.
@en
Crystal structures of bovine c ...... amyloid beta-protein precursor
@nl
prefLabel
Crystal structures of bovine c ...... rs with altered specificities.
@en
Crystal structures of bovine c ...... amyloid beta-protein precursor
@nl
P2093
P2860
P921
P356
P1433
P1476
Crystal structures of bovine c ...... rs with altered specificities.
@en
P2093
Kossiakoff AA
Pelletier LA
Scheidig AJ
P2860
P304
P356
10.1002/PRO.5560060902
P577
1997-09-01T00:00:00Z