The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.
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DNA polymerase family X: function, structure, and cellular rolesUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayA Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active SiteA germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformationThe S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantHuman POLB gene is mutated in high percentage of colorectal tumors.Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.The steric gate of DNA polymerase ι regulates ribonucleotide incorporation and deoxyribonucleotide fidelity.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity.Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
P2860
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P2860
The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年學術文章
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2008年學術文章
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2008年學術文章
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name
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@en
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@nl
type
label
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@en
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@nl
prefLabel
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@en
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@nl
P2093
P2860
P356
P1433
P1476
The Asp285 variant of DNA poly ...... increased nucleotide binding.
@en
P2093
Drew L Murphy
Jessica Kosa
Joachim Jaeger
Joann B Sweasy
P2860
P304
P356
10.1021/BI702104Y
P407
P577
2008-07-11T00:00:00Z