Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.
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Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I.Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.Topoisomerases of kinetoplastid parasites: why so fascinating?Flavone-resistant Leishmania donovani overexpresses LdMRP2 transporter in the parasite and activates host MRP2 on macrophages to circumvent the flavone-mediated cell death.'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani.Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase.
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P2860
Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.
description
2005 nî lūn-bûn
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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name
Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
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Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
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type
label
Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
@en
Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
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Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
@en
Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
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P2093
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Topoisomerase I amino acid sub ...... stance in Leishmania donovani.
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Isabelle Hardy
Jean-François Marquis
Martin Olivier
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10.1128/AAC.49.4.1441-1446.2005
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2005-04-01T00:00:00Z