Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo.
about
Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenograftsNew highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.Irinotecan hydrochloride for the treatment of recurrent and refractory non-Hodgkin lymphoma: a single institution experience.Metastatic liver tumors.Treatment of adult T-cell leukaemia-lymphoma with irinotecan hydrochloride (CPT-11). CPT-11 Study Group on Hematological Malignancy.A phase II trial of combination of CPT-11 and cisplatin for advanced non-small-cell lung cancer. CPT-11 Lung Cancer Study Group.CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated proteinPhase I study of cisplatin, irinotecan, and epirubicin administered every 3 weeks in patients with advanced solid tumoursIrinotecan plus gemcitabine vs irinotecan for the second-line treatment of patients with advanced non-small-cell lung cancer pretreated with docetaxel and cisplatin: a multicentre, randomised, phase II study.Cancer therapies utilizing the camptothecins: a review of the in vivo literatureMechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma.New strategy for overcoming resistance to chemotherapy of ovarian cancer.In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.New natural products in cancer chemotherapy.N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.Therapeutic potential and molecular mechanism of a novel sulfonamide anticancer drug, indisulam (E7070) in combination with CPT-11 for cancer treatment.Mechanisms of multidrug resistance and implications for therapy.Topoisomerase I inhibitors and drug resistanceDE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f: potent antitumor activities in various murine tumor models.Sensitivity to anticancer agents and resistance mechanisms in clear cell carcinoma of the ovary.Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma.CPT-11. The European experience.Cellular resistance to camptothecins.Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks.Clinical pharmacology and pharmacodynamics of irinotecan. A review.Preclinical antitumor activity and pharmacokinetics of irinotecan (CPT-11) in tumor-bearing mice.Camptothecin and its analogs. An overview of their potential in cancer therapeutics.Synergistic enhancement of cisplatin cytotoxicity by SN-38, an active metabolite of CPT-11, for cisplatin-resistant HeLa cells.Formulation and evaluation of irinotecan suppository for rectal administration.Current perspectives on camptothecins in cancer treatmentCombined inhibition of topoisomerases I and II--is this a worthwhile/feasible strategy?Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats.In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38.Xeroderma pigmentosum complementation group D polymorphism toward lung cancer susceptibility survival and response in patients treated with platinum chemotherapy.Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11.Relationship between the pharmacokinetics of irinotecan and diarrhea during combination chemotherapy with cisplatin.Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate.Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.
P2860
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P2860
Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@en
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@nl
type
label
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@en
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@nl
prefLabel
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@en
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@nl
P2093
P356
P1476
Antitumor effect of CPT-11, a ...... t tumors in vitro and in vivo.
@en
P2093
P2888
P356
10.1007/BF00262744
P577
1988-01-01T00:00:00Z
P6179
1012762193