Sequential checkpoints govern substrate selection during cotranslational protein targeting.
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The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevanceA tale of two GTPases in cotranslational protein targetingStructures of the E. coli translating ribosome with SRP and its receptor and with the translocon.Structural basis of signal sequence surveillance and selection by the SRP–FtsY complexCrystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactionsYlxM is a newly identified accessory protein that influences the function of signal recognition particle pathway components in Streptococcus mutansDirect visualization reveals dynamics of a transient intermediate during protein assembly.Activated GTPase movement on an RNA scaffold drives co-translational protein targetingStructure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targetingSignal recognition particle-ribosome binding is sensitive to nascent chain length.Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.Allosteric response and substrate sensitivity in peptide binding of the signal recognition particle.Molecular mechanism of co-translational protein targeting by the signal recognition particleHeat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli.Signal recognition particle and SecA cooperate during export of secretory proteins with highly hydrophobic signal sequences.Regulation by a chaperone improves substrate selectivity during cotranslational protein targetingTranslation elongation regulates substrate selection by the signal recognition particle.Dynamics of co-translational protein targeting.Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocationFingerloop activates cargo delivery and unloading during cotranslational protein targetingProtein translocation across the rough endoplasmic reticulum.A Novel SRP Recognition Sequence in the Homeostatic Control Region of Heat Shock Transcription Factor σ32.Tail-anchored membrane protein insertion into the endoplasmic reticulum.Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway.Staying on message: ensuring fidelity in pre-mRNA splicing.Breaking on through to the other side: protein export through the bacterial Sec system.Signal recognition particle: an essential protein-targeting machine.Co-translational protein targeting to the bacterial membrane.The Sec translocon mediated protein transport in prokaryotes and eukaryotes.Fidelity of cotranslational protein targeting by the signal recognition particle.Site-specific fluorescent labeling of nascent proteins on the translating ribosome.Enhancing full-length antibody production by signal peptide engineering.UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.ATPase and GTPase Tangos Drive Intracellular Protein Transport.Multiple selection filters ensure accurate tail-anchored membrane protein targeting.Structures of the scanning and engaged states of the mammalian SRP-ribosome complex.Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting.Signal-sequence induced conformational changes in the signal recognition particle.
P2860
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P2860
Sequential checkpoints govern substrate selection during cotranslational protein targeting.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Sequential checkpoints govern ...... anslational protein targeting.
@en
Sequential checkpoints govern ...... anslational protein targeting.
@nl
type
label
Sequential checkpoints govern ...... anslational protein targeting.
@en
Sequential checkpoints govern ...... anslational protein targeting.
@nl
prefLabel
Sequential checkpoints govern ...... anslational protein targeting.
@en
Sequential checkpoints govern ...... anslational protein targeting.
@nl
P2093
P2860
P356
P1433
P1476
Sequential checkpoints govern ...... anslational protein targeting.
@en
P2093
Rumana Rashid
Shu-ou Shan
P2860
P304
P356
10.1126/SCIENCE.1186743
P407
P577
2010-05-01T00:00:00Z