Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.
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Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trendWhat does our genome encode?Defining functional DNA elements in the human genomeGenomic views of distant-acting enhancersUltraconserved elements: analyses of dosage sensitivity, motifs and boundariesVariation in vertebrate cis-regulatory elements in evolution and diseasePhylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence DivergenceFunction and regulation of AUTS2, a gene implicated in autism and human evolutionSequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergencesDevelopment of the zebrafish enteric nervous system.Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to NeurodegenerationChIP-seq accurately predicts tissue-specific activity of enhancersPervasive divergence of transcriptional gene regulation in Caenorhabditis nematodesLocal conservation scores without a priori assumptions on neutral substitution rates.Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish.Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes.Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's diseaseComparative analyses of vertebrate posterior HoxD clusters reveal atypical cluster architecture in the caecilian Typhlonectes natansIntegrating multiple evidence sources to predict transcription factor binding in the human genome.A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo.A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.Genome-wide identification of conserved regulatory function in diverged sequencesDistinct functional constraints partition sequence conservation in a cis-regulatory elementDissecting the transcriptional regulatory properties of human chromosome 16 highly conserved non-coding regionsConserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genesDNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.Multiple enhancers located in a 1-Mb region upstream of POU3F4 promote expression during inner ear development and may be required for hearingEvolution of transcription factor binding in metazoans - mechanisms and functional implications.Transcriptional enhancers in protein-coding exons of vertebrate developmental genes.The importance of being cis: evolution of orthologous fish and mammalian enhancer activity.Computational identification of active enhancers in model organisms.A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in femalesIntegrating diverse datasets improves developmental enhancer predictionConservation of transcription factor binding events predicts gene expression across species.Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer.Towards resolving the transcription factor network controlling myelin gene expressionSystematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation.Discriminative prediction of mammalian enhancers from DNA sequence.A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.
P2860
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P2860
Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@en
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@nl
type
label
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@en
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@nl
prefLabel
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@en
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@nl
P2093
P2860
P356
P1433
P1476
Metrics of sequence constraint ...... exhaustive analysis at phox2b.
@en
P2093
Amr Al-Saif
Andrew S McCallion
Jimmy Huynh
Michael A Beer
Ryan M Vinton
P2860
P304
P356
10.1101/GR.6929408
P577
2007-12-10T00:00:00Z