Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. - Wikidata - awgldk - TriplyDB

Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.

Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.

http://www.wikidata.org/entity/Q42239743

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Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend What does our genome encode?Defining functional DNA elements in the human genome Genomic views of distant-acting enhancers Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries Variation in vertebrate cis-regulatory elements in evolution and disease Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence Function and regulation of AUTS2, a gene implicated in autism and human evolution Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences Development of the zebrafish enteric nervous system.Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration ChIP-seq accurately predicts tissue-specific activity of enhancers Pervasive divergence of transcriptional gene regulation in Caenorhabditis nematodes Local conservation scores without a priori assumptions on neutral substitution rates.Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish.Alu and b1 repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes.Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease Comparative analyses of vertebrate posterior HoxD clusters reveal atypical cluster architecture in the caecilian Typhlonectes natans Integrating multiple evidence sources to predict transcription factor binding in the human genome.A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo.A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.Genome-wide identification of conserved regulatory function in diverged sequences Distinct functional constraints partition sequence conservation in a cis-regulatory element Dissecting the transcriptional regulatory properties of human chromosome 16 highly conserved non-coding regions Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.Multiple enhancers located in a 1-Mb region upstream of POU3F4 promote expression during inner ear development and may be required for hearing Evolution of transcription factor binding in metazoans - mechanisms and functional implications.Transcriptional enhancers in protein-coding exons of vertebrate developmental genes.The importance of being cis: evolution of orthologous fish and mammalian enhancer activity.Computational identification of active enhancers in model organisms.A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females Integrating diverse datasets improves developmental enhancer prediction Conservation of transcription factor binding events predicts gene expression across species.Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer.Towards resolving the transcription factor network controlling myelin gene expression Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation.Discriminative prediction of mammalian enhancers from DNA sequence.A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.

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P2860

Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b.

http://www.wikidata.org/entity/Q42239743

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2007 nî lūn-bûn

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Genome Research

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Metrics of sequence constraint ...... exhaustive analysis at phox2b.

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Amr Al-Saif

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Andrew S McCallion

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Jimmy Huynh

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Michael A Beer

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Ryan M Vinton

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Highly conserved non-coding sequences are associated with vertebrate development

Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.

Stages of embryonic development of the zebrafish

Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

Aligning multiple genomic sequences with the threaded blockset aligner

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10.1101/GR.6929408

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2

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18

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David M McGaughey

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2007-12-10T00:00:00Z

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5777412

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18071029

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2203623

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