The competitive binding between inhibitors and substrates of HCV NS3/4A protease: a general mechanism of drug resistance.
about
Comparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strainsApplications of computer-aided approaches in the development of hepatitis C antiviral agents.The NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region.Identification of potential inhibitors for HCV NS3 genotype 4a by combining protein-ligand interaction fingerprint, 3D pharmacophore, docking, and dynamic simulation.Role of R292K mutation in influenza H7N9 neuraminidase toward oseltamivir susceptibility: MD and MM/PB(GB)SA study.Exploring resistance mechanisms of HCV NS3/4A protease mutations to MK5172: insight from molecular dynamics simulations and free energy calculations.Computational study on the drug resistance mechanism of HCV NS3 protease to BMS-605339.Theoretical studies on the selective mechanisms of GSK3β and CDK2 by molecular dynamics simulations and free energy calculations.
P2860
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P2860
The competitive binding between inhibitors and substrates of HCV NS3/4A protease: a general mechanism of drug resistance.
description
2014 nî lūn-bûn
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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2014年论文
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2014年论文
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name
The competitive binding betwee ...... mechanism of drug resistance.
@en
The competitive binding betwee ...... mechanism of drug resistance.
@nl
type
label
The competitive binding betwee ...... mechanism of drug resistance.
@en
The competitive binding betwee ...... mechanism of drug resistance.
@nl
prefLabel
The competitive binding betwee ...... mechanism of drug resistance.
@en
The competitive binding betwee ...... mechanism of drug resistance.
@nl
P2093
P1433
P1476
The competitive binding betwee ...... mechanism of drug resistance.
@en
P2093
P356
10.1016/J.ANTIVIRAL.2014.01.010
P577
2014-01-23T00:00:00Z