Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
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The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosisPD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cellsReduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infectionIncomplete CD8(+) T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigenLiver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.A multifactorial mechanism in the superior antimalarial activity of alpha-C-GalCer.Understanding the mechanism of action of bacterial superantigens from a decade of research.Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors.Antigen decoding by T lymphocytes: from synapses to fate determination.Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression.Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cellsRetina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporinThe response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion.Small molecule inhibition of Csk alters affinity recognition by T cells.Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli.CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimersRestricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells.T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization.CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cellsTreatment with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection.Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells.Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation.Mechanisms of cellular communication through intercellular protein transfer.Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity.Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways.Masking of the CD3 gamma di-leucine-based motif by zeta is required for efficient T-cell receptor expression.A role for the cytoplasmic tail of the pre-T cell receptor (TCR) alpha chain in promoting constitutive internalization and degradation of the pre-TCR.On the Mechanism of T cell receptor down-modulation and its physiological significance.T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cellsReceptor engagement transiently diverts the T cell receptor heterodimer from a constitutive degradation pathway.Antigen-induced TCR-CD3 down-modulation does not require CD3delta or CD3gamma cytoplasmic domains, necessary in response to anti-CD3 antibody.Understanding the mechanisms of sustained signaling and T cell activation.Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal.Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation.
P2860
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P2860
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@en
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@nl
type
label
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@en
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@nl
prefLabel
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@en
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@nl
P2093
P2860
P356
P1476
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells
@en
P2093
P2860
P304
P356
10.1084/JEM.185.4.641
P407
P577
1997-02-01T00:00:00Z