Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.
about
Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice culturesInhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASEGenetic of Alzheimer's Disease: A Narrative Review ArticleProtein partners of dynamin-1 in the retinaMeta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's diseaseNicotine modulates expression of dynamin 1 in rat brain and SH-SY5Y cells.Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses.Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform.Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure.Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease.Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementiaCalpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity.Calpain dysregulation in Alzheimer's diseaseAmyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons.Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons.Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genesNecrosis- and apoptosis-related Met cleavages have divergent functional consequencesUpregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationIs Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid.Basic mechanisms of neurodegeneration: a critical update.Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.Dynamin-2 in nervous system disorders.GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease.Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Enhanced mossy fiber sprouting and synapse formation in organotypic hippocampal cultures following transient domoic acid excitotoxicity.Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons.Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity.Dynamins at a glanceThe novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.Tau45-230 association with the cytoskeleton and membrane-bound organelles: Functional implications in neurodegeneration.Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.
P2860
Q24603101-25A2971D-7299-4277-957F-2847D29E0E08Q24813188-EAD06F6F-62BF-4A82-AAB3-95E999484285Q26740104-34B537A9-9A66-4755-997B-5F69AABE7A61Q27007467-4D1D22B6-0F95-402B-A337-F2A01046C49CQ28585162-6320C74E-AA25-4A4A-BBAC-C42B86DD64CFQ28742427-793B67A2-72F4-4B36-8EB8-C5B2A47399DAQ30428397-71786207-E3F7-414F-8415-965380CB5AA1Q33360444-36F6F36D-1487-4F66-82E5-3CCF58D6C007Q33371464-C595DAF2-7CEE-4488-90BD-DB5ED190048AQ33522912-9034CF6B-2F79-4AB8-9004-F32D6403A19FQ33593939-CB4E353F-97E3-4034-AE69-60748063DF35Q34006251-FB077F6B-E9FC-4927-9837-B211214F7F72Q35016920-C802AD3F-27B2-4513-82B7-1CD790DCB67BQ35022169-654CADC2-7D48-4A9E-BA4C-EA0C82171E15Q35080456-AB960B29-3685-4290-9E60-F7536395618AQ35177482-5B4784A5-597D-46D3-A05E-4DC47BC90005Q35361462-68A0825F-B8F4-4873-90C2-EFA572F395E3Q35576030-2D676188-4759-4EBD-8AD0-C0D7DC007597Q35872520-D3F3E935-753B-47CB-9CBD-355FBE770886Q35955892-5227203B-1E65-40B9-9379-C46737CFDB2BQ36166587-5C78315E-64E4-448D-B318-311BD684EAC9Q36346969-D7EB6714-A9ED-490E-97E9-596A17F2B705Q36758446-DE836A2A-3D1E-46CA-8F3D-51016F28E80FQ36778260-9C5154D5-59C0-41CD-8753-F8997D2DDF90Q36869427-FFBB3852-DA78-4341-B318-B58CEFAAE137Q37237452-DA7B589C-22CF-478D-8262-FAF44F8C27B0Q37519545-95E3E21C-21D9-449A-BD94-47A0581540C3Q37673274-C8DAA1EB-E7E2-410E-B5D4-BCFF34C0363CQ38026045-F36164B6-93BA-448E-ADD8-C7D38F9B7C95Q38150395-FF383801-0B56-45CC-B41B-CA2CB15545BFQ38225536-9B015735-6A1B-4F8B-B47B-1255E946434FQ38731291-8468CBB1-0109-43C6-8AAD-E88B5803CC6AQ39164408-2533CD30-55D7-4CEA-A5DF-9E07B406ACBCQ39292803-6948AC90-D4E1-491C-8A2C-9751893390ECQ41437626-BE16CAB4-079D-42D3-B1C8-1734FC96D787Q41995769-8EE5675B-42B6-46EA-8C4E-E403D44C69FEQ42558894-7AD3001E-64AD-4E88-BE90-7668423D3EEBQ43213857-13153722-1E26-4492-BF82-FE65B015EA39Q47900700-E4BAEBF8-90AB-4215-9DDB-82C971DFC9DDQ48513874-31FA1C42-09A4-4F26-95FD-57F1158C4290
P2860
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@en
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@nl
type
label
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@en
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@nl
prefLabel
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@en
Beta-amyloid-induced dynamin 1 ...... decline in Alzheimer disease.
@nl
P2860
P356
P1476
Beta-amyloid-induced dynamin 1 ...... e decline in Alzheimer disease
@en
P2093
Brent L Kelly
Robert Vassar
P2860
P304
31746-31753
P356
10.1074/JBC.M503259200
P407
P577
2005-07-07T00:00:00Z