about
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analoguesFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug designInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionTargeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.Recent advances in cancer therapeutics.Lysine-Targeting Covalent Inhibitors.Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.Cancer Drug Discovery 2010: from molecules to medicine.Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.Privileged Structures and Polypharmacology within and between Protein Families.A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylationA model β-sheet interaction and thermodynamic analysis of β-strand mimeticsThe synthesis and structure revision of NSC-134754Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Keith Jones
@ast
Keith Jones
@en
Keith Jones
@es
Keith Jones
@nl
Keith Jones
@sl
كيث جونز
@ar
type
label
Keith Jones
@ast
Keith Jones
@en
Keith Jones
@es
Keith Jones
@nl
Keith Jones
@sl
كيث جونز
@ar
prefLabel
Keith Jones
@ast
Keith Jones
@en
Keith Jones
@es
Keith Jones
@nl
Keith Jones
@sl
كيث جونز
@ar
P106
P21
P31
P496
0000-0002-9440-4094