Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes.

about

Pevonedistat, a first-in-class NEDD8-activating enzyme (NAE) inhibitor, combined with azacitidine, in patients with AML.

P2860

Q48216923-714A55B6-2C88-4FBC-AA8E-211B404D579B

P2860

Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes.

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http://www.wikidata.org/entity/Q42292376

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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P1476

Expanded safety analysis of pe ...... and myelodysplastic syndromes.

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P2093

B C Medeiros

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B J Dezube

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D J DeAngelo

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F J Giles

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F Sedarati

http://www.w3.org/2001/XMLSchema#string

H Faessel

http://www.w3.org/2001/XMLSchema#string

H P Erba

http://www.w3.org/2001/XMLSchema#string

H Stein

http://www.w3.org/2001/XMLSchema#string

J K Altman

http://www.w3.org/2001/XMLSchema#string

J Watts

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P2860

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.

Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study.

Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors.

Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system.

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

Neddylation plays an important role in the regulation of murine and human dendritic cell function.

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

P2888

bcj.2017.1

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e520

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scholarly article

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10.1038/BCJ.2017.1

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Faiz Anwer

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1083525975

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Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes.

about

P2860

P2860

Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes.

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