about
SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease.Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target.Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.An Updated Test of AMBER Force Fields and Implicit Solvent Models in Predicting the Secondary Structure of Helical, β-Hairpin, and Intrinsically Disordered Peptides.Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities.A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversalβ-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.Virtual screening approach for the identification of new Rac1 inhibitors.A highly diastereoselective synthesis of α-hydroxy-β-amino acid derivatives via a Lewis acid catalyzed three-component condensation reaction.Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans.Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids.Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts.Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn.Molecular insights into dimerization inhibition of c-Maf transcription factorTetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn ConformationsModel peptides containing the 3-sulfanyl-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310-helix secondary structuresAsymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride ReductionComputational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxideOrigin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based PeptidesMechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids[2 + 4] and [4 + 2] cycloadditions of o-thioquinones with 1,3-dienes: a computational studyTautomeric equilibria of [1]benzopyrano[3,4-d]imidazol-4(3H)-ones, a theoretical and NMR studyIsothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxidesExpedient chemical synthesis of 75mer DNA binding domain of MafA: an insight on its binding to insulin enhancer1H-Azepine-4-amino-4-carboxylic acid: a new α,α-disubstituted ornithine analogue capable of inducing helix conformations in short Ala-Aib pentapeptidesSynthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imidesMolecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitorsVCD spectroscopy as an excellent probe of chiral metal complexes containing a carbon monoxide vibrational chromophoreStereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligandRescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric ConstantsIdentification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alessandro Contini
@ast
Alessandro Contini
@en
Alessandro Contini
@es
Alessandro Contini
@nl
type
label
Alessandro Contini
@ast
Alessandro Contini
@en
Alessandro Contini
@es
Alessandro Contini
@nl
prefLabel
Alessandro Contini
@ast
Alessandro Contini
@en
Alessandro Contini
@es
Alessandro Contini
@nl
P1053
F-5064-2012
P106
P1153
7003441091
P21
P2798
P31
P3829
P496
0000-0002-4394-8956