Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.
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The benefits of humanized yeast models to study Parkinson's diseasePhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseC-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbs proteostasis in a yeast modelBoth ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding ProcessInhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.From the baker to the bedside: yeast models of Parkinson's disease.Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions.Yeast models for amyloid disease.Behead and live long or the tale of cathepsin L.Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1.Rapid Nuclear Exclusion of Hcm1 in Aging Saccharomyces cerevisiae Leads to Vacuolar Alkalization and Replicative Senescence.Sumoylation Protects Against β-Synuclein Toxicity in Yeast.(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
P2860
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P2860
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@en
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@nl
type
label
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@en
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@nl
prefLabel
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@en
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@nl
P2093
P2860
P921
P356
P1476
Aggregate clearance of α-synuc ...... nction than on the proteasome.
@en
P2093
Blagovesta Popova
Doris Petroi
Hedieh Shahpasandzadeh
Naimeh Taheri-Talesh
Stefan Irniger
Tiago F Outeiro
P2860
P304
27567-27579
P356
10.1074/JBC.M112.361865
P407
P577
2012-06-21T00:00:00Z