about
The mechanisms of DNA topoisomerasesReduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approachProduction of highly knotted DNA by means of cosmid circularization inside phage capsidsGenome urbanization: clusters of topologically co-regulated genes delineate functional compartments in the genome of Saccharomyces cerevisiae.Expression of transgenic PPP1CC2 in the testis of Ppp1cc-null mice rescues spermatid viability and spermiation but does not restore normal sperm tail ultrastructure, sperm motility, or fertility.DNA knots reveal a chiral organization of DNA in phage capsids.Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.Topoisomerase II regulates yeast genes with singular chromatin architectures.Topoisomerase II: a fitted mechanism for the chromatin landscape.Transcriptional inhibition by DNA torsional stress.Positional dependence of transcriptional inhibition by DNA torsional stress in yeast chromosomes.Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage.Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils.Topoisomerase II is required for the production of long Pol II gene transcripts in yeast.Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA.Structure and Chromosomal Organization of Yeast Genes Regulated by Topoisomerase II.The path of the DNA along the dimer interface of topoisomerase II.DNA knots occur in intracellular chromatin.DNA Topology and Global Architecture of Point Centromeres.Failure to relax negative supercoiling of DNA is a primary cause of mitotic hyper-recombination in topoisomerase-deficient yeast cells.A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II.Intracellular nucleosomes constrain a DNA linking number difference of -1.26 that reconciles the Lk paradoxQuantitative disclosure of DNA knot chirality by high-resolution 2D-gel electrophoresisThe capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerasesDNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanismAsymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topologyFractal dimension and localization of DNA knotsIn silico, in vitro and in vivo imageries of type II topoisomerases: Comment on "Disentangling DNA molecules" by Alexander VologodskiiElectrophoretic Analysis of the DNA Supercoiling Activity of DNA GyraseTranscriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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Joaquim Roca
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7101624422
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joaquim-roca2
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