Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells. - Wikidata - awgldk - TriplyDB

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

http://www.wikidata.org/entity/Q42325260

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Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.Follicular helper T cell signature in type 1 diabetes Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients.Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease.Regulatory T cell induction, migration, and function in transplantation.Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity.Treg and CTLA-4: two intertwining pathways to immune tolerance.Mobilizing and evaluating anticancer T cells: pitfalls and solutions.T-cell costimulatory blockade in organ transplantation.Targeting CD28 to prevent transplant rejection.Therapeutic use of anti-CTLA-4 antibodies.Overcoming tumor-mediated immunosuppression.Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.Confusing signals: recent progress in CTLA-4 biology Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4+ regulatory T cell subsets circulating in human malaria.A cellular platform for the evaluation of immune checkpoint molecules.CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival.CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.

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Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

http://www.wikidata.org/entity/Q42325260

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Cutting edge: cell-extrinsic i ...... essed on conventional T cells.

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JIMMUNOL.1200972

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Journal of Immunology

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Cutting edge: cell-extrinsic i ...... essed on conventional T cells.

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Chun Jing Wang

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Emily M Schmidt

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Lucy S K Walker

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Lukasz Wardzinski

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Omar S Qureshi

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Rupert Kenefeck

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P2860

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

CTLA-4 ligation blocks CD28-dependent T cell activation

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

CTLA-4 can function as a negative regulator of T cell activation

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

CTLA-4 control over Foxp3+ regulatory T cell function

Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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1118-1122

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scholarly article

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10.4049/JIMMUNOL.1200972

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3

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189

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Kesley Attridge

Claire Manzotti

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2012-06-29T00:00:00Z

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228105714

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3442233

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