Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
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Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic TregsStructural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumabCandida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockadeHigh CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belataceptOpposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.Follicular helper T cell signature in type 1 diabetesIpilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients.Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG MicePreclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque ToxicologyA SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD MouseTreatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cellsCancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease.Regulatory T cell induction, migration, and function in transplantation.Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity.Treg and CTLA-4: two intertwining pathways to immune tolerance.Mobilizing and evaluating anticancer T cells: pitfalls and solutions.T-cell costimulatory blockade in organ transplantation.Targeting CD28 to prevent transplant rejection.Therapeutic use of anti-CTLA-4 antibodies.Overcoming tumor-mediated immunosuppression.Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.Confusing signals: recent progress in CTLA-4 biologyImmunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4+ regulatory T cell subsets circulating in human malaria.A cellular platform for the evaluation of immune checkpoint molecules.CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival.CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.
P2860
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P2860
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@en
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@nl
type
label
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@en
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@nl
prefLabel
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@en
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@nl
P2093
P2860
P50
P356
P1476
Cutting edge: cell-extrinsic i ...... essed on conventional T cells.
@en
P2093
Chun Jing Wang
Emily M Schmidt
Lucy S K Walker
Lukasz Wardzinski
Omar S Qureshi
Rupert Kenefeck
P2860
P304
P356
10.4049/JIMMUNOL.1200972
P407
P577
2012-06-29T00:00:00Z