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Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activityOn the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferensAnalysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MSCloning of linoleate diol synthase reveals homology with prostaglandin H synthases.Cloning of the manganese lipoxygenase gene reveals homology with the lipoxygenase gene family.Expression of manganese lipoxygenase in Pichia pastoris and site-directed mutagenesis of putative metal ligands.Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn.Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases.Manganese lipoxygenase. Purification and characterization.Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction.A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.Crystallization and preliminary crystallographic analysis of manganese lipoxygenaseSecretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii.Biochemical characterization of the oxygenation of unsaturated fatty acids by the dioxygenase and hydroperoxide isomerase of Pseudomonas aeruginosa 42A2.CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.Expression of fusion proteins of Aspergillus terreus reveals a novel allene oxide synthase.Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases.Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes.Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid.A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum.Gene deletion of 7,8-linoleate diol synthase of the rice blast fungus: studies on pathogenicity, stereochemistry, and oxygenation mechanisms.Liquid chromatography/tandem mass spectrometric analysis of 7,10-dihydroxyoctadecenoic acid, its isotopomers, and other 7,10-dihydroxy fatty acids formed by Pseudomonas aeruginosa 42A2.LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22.Cloning and characterization of CYP4F21: a prostaglandin E2 20-hydroxylase of ram seminal vesicles.Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies.7,8- and 5,8-Linoleate diol synthases support the heterolytic scission of oxygen-oxygen bonds by different amide residues.Metabolism of 18:2(n - 6), 18:3(n - 3), 20:4(n - 6) and 20:5(n - 3) by the fungus Gaeumannomyces graminis: identification of metabolites formed by 8-hydroxylation and by w2 and w3 oxygenation.Linoleate diol synthase of the rice blast fungus Magnaporthe grisea.Biosynthesis and isomerization of 11-hydroperoxylinoleates by manganese- and iron-dependent lipoxygenases.Biosynthesis of epoxyeicosatrienoic acids varies between polymorphic CYP2C enzymes.Critical amino acids for the 8(R)-dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases.Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry.Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat.Factors influencing the rearrangement of bis-allylic hydroperoxides by manganese lipoxygenase.Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.cDNA cloning of 15-lipoxygenase type 2 and 12-lipoxygenases of bovine corneal epithelium.Oxidation of prostaglandin H2 and prostaglandin H2 analogues by human cytochromes P450: analysis of ω-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I1 by mass spectrometry11Abbreviations: CYP, cytochrome P450; HHT, (
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Ernst H. Oliw
@ast
Ernst H. Oliw
@en
Ernst H. Oliw
@es
Ernst H. Oliw
@nl
Ernst H. Oliw
@sl
type
label
Ernst H. Oliw
@ast
Ernst H. Oliw
@en
Ernst H. Oliw
@es
Ernst H. Oliw
@nl
Ernst H. Oliw
@sl
prefLabel
Ernst H. Oliw
@ast
Ernst H. Oliw
@en
Ernst H. Oliw
@es
Ernst H. Oliw
@nl
Ernst H. Oliw
@sl
P106
P1153
7005137963
P21
P31
P496
0000-0002-7986-8130